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KMID : 0043319980210060774
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Archives of Pharmacal Research
1998 Volume.21 No. 6 p.774 ~ p.778
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Effects of Brazilin on the Phospholipase A2 Activity and Changes on Intracellular Free Calcium Concentration in Rat Platelets
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Hwang Gwi-Seo
Kim Ji-Young
Chang Tong-Shin
Jeon Sun-Duck
So Dhong-Su
Moon Chang-Kiu
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Abstract
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Brazilin [7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol] inhibited thrombin-, collagen- and ADP-induced aggregation of washed rat platelets. T hrombin- and collagen-induced ATP release were also inhibited by brazilin in a concentration-dependent manner. Brazilin inhibited the formation of platelet thromboxane caused by thrombin, whereas it had no effect on the prostaglandin formation. Brazilin inhibited -arachidonic acid liberation from membrane phospholipids of thrombin-stimulated platelets. Brazilin inhibited the rise of intracellular free calcium caused by thrombin. These results indicate that the inhibition of phospholipase () activity and [ elevation might be at least a part of antiplatelet mechanism of brazilin.
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KEYWORD
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Brazilin, Caesalpinia sappan, Aggregation, Phospholipase A2, Platelt, Intracellular free calcium
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